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The study was approved by the Animal Experimentation Ethics Committees of University of Campinas (CEUA/UNIMCAP, protocol 4557-1(A)/2018)

One-way ANOVA along with multiple comparison tests was utilized for multi-group comparisons, and two-tailed Students t-tests were used for single-pair comparisons

They have issued many draft or final guidance, published papers, hosted MIDD-centric workshops, designated regulatory pilot programs, or formed modeling & simulation working group [47,48,49,50]