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In addition, the GPx1 regulation of local H 2 O 2 level realized by binding TRAF2 is distinct from the regulatory action of Prx1, which forms a mixed disulfide with ASK1 to relay the oxidation signal 47

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Notably, while excess iodine is well known to trigger thyroid autoimmunity in susceptible individuals, evidence from the literature is reassuring that an adequate iodine status (defined as a UIC between 100 g/L and 299 g/L) is safe in this regard [25, 26]

Future efforts should focus on improving sensitivity, standardization, and accessibility, while leveraging single-cell and spatial omics to capture intratumoral heterogeneity and accelerating the translation of these methodologies into clinical practice