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Neither is a failure of the molecule

In both animal models and controlled human studies, DSIP has been associated with modulation of endogenous sleep-regulating systems rather than direct sedative activity, supporting its classification as a neuromodulator rather than a pharmacological hypnotic agent [2]

This process of retrograde signaling or mitochondria talking to the nucleus is a newly recognized aspect of cell biology, and MOTS-c is one of the best examples we know of

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