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Oral capsule considerations: Estimated bioavailability : 60-80% (based on molecular properties) Time to peak effect : 1-2 hours post-administration Duration of action : 4-8 hours (approximate) Food interaction : May be taken with or without food, though consistent timing recommended Dosing adjustments for oral route: Standard doses (50-100mg) typically used without modification Absorption may vary based on digestive factors Consistent timing relative to meals improves reproducibility Sublingual Administration Some researchers prefer sublingual (under the tongue) administration for potentially enhanced absorption and faster onset

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placebo-treated patients achieved similar final levels of improvement, after additional sessions (Kushner et al., 2007)