nac apap overdose mechanism glutathione The Metabolism of Acetaminophen and the Synthesis of 🔆 Acetaminophen (Paracetamol) Toxicity A

Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration 5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. 54 Anesthesia Key Acetaminophen metabolism

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