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For each included study, the following information was collected: first authors name, year of publication, country of origin, type of study (in vitro, in vivo, or clinical), characteristics of the experimental model (e.g., species, sample size), specific platelet-derived product used (PRP, PRGF, PRF, or PRPL), details of preparation protocols, route and frequency of administration, and main outcome measures

For 13 C-labeled metabolites, we retrieved their metabolic reaction relationship from metabolic reaction network curated using the KEGG database, which results in reaction pairs (RPs) between labeled metabolites (Fig

The term scatter factor was later introduced independently in 1985 by Stoker and co-workers, as they discovered a protein interrupting the intracellular junctions of epithelial cells thereby promoting their migration in a paracrine manner and promoting an invasive phenotype [4]

Often the pain we experience is the result of ongoing inflammatory processes in our body