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10.1016/s0006-3495(93)81101-9 Biophys

"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1"

Pancreatic cancer is a cancer of epithelial origin, and therefore it is expected that many of the same pathways will be implicated in other epithelial cancers, such as breast cancer, uterine cancer, esophogeal cancer, liver cancer, etc

Specifically, in March 2024, resmetirom, a thyroid hormone receptor- agonist [126], was the first drug approved by the United States Food and Drug Administration (FDA) [125]