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FIGURE 2 In the reverse perspective, production of cellular ROS is also associated with fibrillation of -synuclein (Esteves et al., 2008)

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24 h) alleviates A 25-35 -induced synaptic dysfunction in primary rat hippocampal neurons in an in vitro ER-dependent manner, as its protective effects on electrophysiological function are eliminated when ER is knocked down [4]

In turn, methionine transfers its methyl-unit via the S-adenosylmethionine/S-adenosylhomocysteine cycle to numerous metabolites and macromolecules for methylation of, e.g., lipids, proteins and DNA