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In a randomized clinical trial comparing oral and parenteral therapy, both groups showed similar reductions in mean corpuscular volume and increases in hematocrit at 4 months.11 The present case highlights the causal relationship between vitamin B12 deficiency and generalized skin hyperpigmentation, an association that presents a wide variety of dermatological manifestations

Haro C, Villena J, Zelaya H, Alvarez S, Agero G

Cobalamin supplementation improves motor development and regurgitations in infants: results from a randomized intervention study