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The relationship between this response and both glutathione homeostasis and overall antioxidant capacity is not yet clear, and additional research is planned to investigate this further

The data we obtained indicate that the reason for the decrease in the sensitivity of cells with a gmhA deletion to antibiotics is the depletion of the pool of low-molecular-weight thiols, as is observed in violation of the metabolism of cysteine and glutathione, while an increase in the content of cystine, the oxidized form of cysteine, or cysteine leads to an increase in the sensitivity of these cells to antibiotics

Studies summarized by presenting graphical representations of the data in SupplementalFigures 1-Table 7 and Supplemental Table 7)

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