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SIPS plays a key role in regulating cell metabolism and function 18

These results indicate that the reduction in mitochondrial NAD+ preservation may be a substantial cardiomyocyte senescence-inducing factor, manifested by the decrease in adaptability to adverse homeostasis changes, such as high glucose, hypoxia, drug stress, or ischemiareperfusion (I/R) injury [7]

Later studies (150) evaluated the possibility of VEGF-A, VEGF-D and soluble vascular endothelial cell growth factor receptor-2 (sVEGFR-2) serving as the response biomarkers of resistance or efficacy in ramucirumab and paclitaxel combination

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