But I think when we look at the broader population, over 80% of the chronic disease burden are diseases of nutrition and lifestyle
Experimental studies have shown that oral supplementation with glutamine can significantly decrease the severity of chemotherapy-induced stomatitis, an important cause of morbidity in the treatment of patients with cancer,[85,86] although the dose given and duration of therapy varies widely upon pathological conditions.[87] Other modalities of prevention of chemotherapy-induced mucositis, like oral cooling, granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor and laser, are available, none of them have uniform efficacy.[88] Studies in mice suggest that alanyl-glutamine, not glutamine, speeds intestinal recovery when compared in 5-FU-treated mice, predominantly by enhancing mitotic activity and crypt length.[89] To evaluate the effect of therapeutic interventions in patients with chemotherapy-induced mucositis, testing intestinal permeability via the measurement of[51] Cr-EDTA urinary excretion after oral challenge may be useful as shown in some experiments.[90,91] GLUTAMINE AND PROTECTION AGAINST ANTHRACYCLINE-INDUCED CARDIOTOXICITY Glutamine supplementation maintained cardiac GSH levels in animal models given methotrexate or CP
the density and osmolality of which was modulated according to the type of peritoneal exudates (from a thioglycolatestimulated or an unstimulated animal)
Hiddemann W, Buechner T, Andreeff M , Woermann B, Clarkson B
