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As the core component of class III phosphatidylinositol 3-kinase complex I (PtdIns3K) [99], BECN1 triggers different cell death by cooperating with different partners, and it is also a factor for occurrence of ferroptosis [100]

Whether NAC is effective in replenishing GSH regardless of GSH deficiency is somewhat controversial

The study included 16 patients with T2DM (seven without complications and nine with microvascular complications), along with eight healthy, age- and sex-matched controls

In pancreatic cancer, LAT2 ( SLC7A8 ) was shown to decrease gemcitabine sensitivity by regulating glutamine-dependent mTOR activation to promote proliferation and inhibit apoptosis (Feng et al., 2018)