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Curcumin-inducible HIF-1 degradation has been shown to impede the process of invasive metastasis in colorectal cancer cells by impeding glutamine catabolism through the inhibition of GLS1 and the suppression of EMT [66]

They resulted from various sources such as the over use of pesticides which contained heavy metals that potentially accumulate in the environment over time (Adeniyi et al

Furthermore, nicotinamide adenine dinucleotide phosphate (NADPH), derived from niacin, is crucial in antioxidant defense mechanisms, by aiding in the regeneration of other antioxidants, such as glutathione (13)

doi: 10.3390/agronomy12020276 Summary Keywords climate change, cold stress, crop improvement, low temperature, signaling Citation Roychowdhury R, Das SP, Sarkar P, Khan Z, Kumar A, Sarker U and Sajeevan RS (2025) Physiological, biochemical and molecular signaling basis of cold stress tolerance in plants