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Such metabolic disorders can initiate a cascade of events, including the dysregulation of the tricarboxylic acid cycle (TCA), which is integral to the oxidative phosphorylation processes in cardiac myocytes (6)

Sell NM, Cassidy DJ, McKinley SK, Petrusa E, Gee DW, Antonoff MB , Phitayakorn R

Notably, a recent study demonstrated that Ganoderic acid D overcomes gemcitabine resistance by promoting the degradation of HIF-1 driven by MDM2, which leads to a reduction in glycolysis in triple-negative breast cancer cells (Luo et al., 2024)

Conclusions The anti-CD38 antibodies isatuximab and daratumumab represent important advances in the treatment of patients with RRMM