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In cancer models, capsaicin engages AMPK/AKt/mTOR or AMPK/mTOR pathways to suppress the Warburg effect, inhibit lipogenesis, promote mitochondrial dependent apoptosis, and induce autophagy, collectively restraining malignant phenotypes such as proliferation, migration, invasion, and epithelial mesenchymal transition (30, 35, 36)

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