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10.1021/bi00010a023 Margalit A, Hauser SD, Zweifel BS, Anderson MA, Isakson PC: Regulation of prostaglandin biosynthesis in vivo by glutathione

Target identification and validation Drug targets are biological macromolecules that exhibit pharmacodynamic functions within the body and can be modulated by drugs, such as specific proteins and nucleic acids

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Mutagenesis of the LP-motif of soybean hGS to the AA-motif reduced catalytic efficiency with -alanine by 10-fold, but improved specificity for glycine by ~1,000-fold (Galant et al., 2009)