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Endoplasmic reticulum stress (ERS) has been identified as a major contributor to human diseases, including DM, neurodegenerative disorders, and cancer (Hetz and Papa, 2018)

This review outlines three signaling pathways of DILI: organelle stress, cholestasis, and immune responses, discusses their interplay with oxidative stress, and provides examples of drugs specifically targeting one or more steps in these pathways

Dietary and lifestyle factors of DNA methylation

They enhance the effect of EGF on DNA synthesis and prevent transglutaminase 2 (TG2)-mediated transamidation of the EGFR in hepatocytes by binding to 1-adrenergic receptors (1-ADR) 182,589,590 Additionally, other research suggests that catecholamines also support the proliferation of cholangiocytes and LPCs