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Nrf2 deficient mice were found to have increased NF-B activation, inflammatory cytokines TNF-, IL-1, and IL-6 production, and ICAM-1 expression in brain after traumatic brain injury compared to wild-type mice ( Several natural compounds have been reported to protect against CVDs by targeting both Nrf2 and NF-B signaling pathways

BPC-157 is studied for its potential role in tissue healing and recovery