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In order to build our MSM, we split the conformational space using the Voronoi decomposition, clustering the ligands center of mass and using the cluster centers as seeds

3c, Supplementary Tables 1754 and Supplementary Figs

4) Underexplored therapeutic strategies and safety concerns: Preclinical studies have relied on short-term administration of ferroptosis modulators, but the long-term safety and efficacy of these agents in ADPKD are unknown