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Due to its roles in such a broad array of systems, targeting the ghrelin receptor with agonists or antagonists will not only affect the phenomenon of interest, such as feeding, but will also affect the other systems in which ghrelin is involved, leading to unwanted side effects

Lactobacilli and bifidobacteria are the most commonly used, usually present in dietary supplements or fermented foods such as yogurt and cultured milk (100)

Figure 2: Application of the retrograde nerve repair technique in a complete lesion of the sciatic nerve in a rat

Adding exogenous prominin 2 to prominin-deficient cells can increase the content of MVBs, confirming that the formation of MVBs is dependent on prominin 2