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Cycling is precautionary given limited long-term data, it reduces theoretical risk of receptor desensitization

Modern pharmacological agents such as glucagon-like peptide-1 (GLP-1) receptor agonists and combination glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists have also been shown to improve cardiovascular outcomes in patients with obesity

Nature 605 , 551560 (2022)

Some of the chemicals like arsine halides used in warfare during the First World War owe their toxicity to their ability of binding to protein dithiols