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At this stage, we say the patient has overt or clinical hypothyroidism There is some debate as to the benefit of treating those with sub-clinical hypothyroidism in symptomatic patients with a high TSH, but normal T4 a trial of treatment may be suitable Hypothyroidism is typically treated with a daily dose of thyroxine 1.6 g/kg lean body weight daily

Proc Natl Acad Sci U S A 100: 3525-3530 Chen Z, Gallie DR (2006) Dehydroascorbate reductase affects leaf growth, development, and function

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The primary utility of PCT is therefore to help uncover the presence of systemic bacterial infections such as sepsis, and numerous studies have investigated the potential roles of PCT in diagnosis and management of e.g