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Changes in tissue composition associated with mammary gland growth during lactation in sows

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Chemotaxis The characteristic movement of a cell along a chemical concentration gradient formed by a chemokine or other chemotactic substance

Erythropoietic porphyrias Congenital erythropoietic porphyria (Gunther disease) Epidemiology Very rare Severe Etiology Autosomal recessive Defective uroporphyrinogen-III synthase Pathophysiology Begins in childhood Bone marrow heme biosynthesis impairment Clinical features Severe photosensitivity leads to light-induced damage burning sensation and redness of the skin with blisters that can develop into ulcers scarring, sometimes severe: Scarring of the cornea (blindness) Loss of fingers Loss of facial features Hemolytic anemia: enzyme dysfunction reduces heme levels and accumulated intermediates disrupt the membrane of erythrocytes and their precursors hypersplenism Bone changes Bone marrow hypertrophy pathologic fractures Acral osteolysis Red stained bones Port-wine colored urine Management No causal therapy Avoid exposure to sunlight Erythropoietic protoporphyria Epidemiology: third most common porphyria Genetics: autosomal dominant (defective ferrochelatase) Clinical features After exposure to sunlight: transient cutaneous findings Protoporphyrin gallstones Rare: chronic hepatic involvement Diagnostics: protoporphyrin in feces and blood Management Protection from sunlight, alpha-MSH Ursodeoxycholic acid, cholestyramine Liver/bone marrow transplantation