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Sulfo-polysaccharides (myostatin inhibitors) Myostatin or growth differentiation factor 8 (GDF-8) is a transforming growth factor known as a negative regulator of skeletal muscle hypertrophy [400]

By employing the safe and feasible gene-editing tool CRISPR/Cas9 to engineer T cells, this method can mitigate exhaustion-inducing signaling pathways, preserve antitumor activity, and increase the in vivo persistence of CAR-T cells, thereby further overcoming limitations in cancer therapy (Fig

Inhibitors of bacterial enzymes that produce uremic metabolites, including iodomethylcholine, which inhibits bacterial TMA formation and lowered systemic creatinine levels, is a promising area of research