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Electronic databases such as Medline/PubMed, ScienceDirect, Scopus, TRIP database, and Web of Science were verified to find both pre-clinical pharmacological/immunological studies and clinical trials regarding Taxol derivatives, using for searching the following MeSH terms: Antineoplastic Agents/chemistry, Antineoplastic Agents/pharmacokinetics, Antineoplastic Agents/pharmacology, Apoptosis/drug effects, Clinical Trials as Topic, Drug Resistance, Neoplasm/physiology, Humans, Microtubules/drug effects, Mitosis/drug effects, Neoplasms/drug therapy, Taxoids/chemistry, Taxoids/pharmacokinetics, Taxoids/pharmacology, Paclitaxel, Paclitaxel/administration and dosage, Prostatic Neoplasms, Castration-Resistant/drug therapy, Docetaxel, and Taxoids/therapeutic use. This study analyzed articles that explored the pharmacological, immunological reprogramming, and subcellular analysis of drugs in pre-clinical models using cell lines or animal models

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