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Ng JY, Munford V, Thakar H

Under uninhibited conditions (bottom pathway), the Keap1 sensor targets Nrf2 for proteolysis and degradation

In grass carp, Zhang et al

I have mentioned earlier four types of potential self-sustained inflammatory loops , one formed by the T cell, B cell and monocyte triangle, a second one due to the fact that microglial cells can both produce and be activated by inflammatory cytokines, a third one due to excessive unbuffered ROS levels and damaged mitochondria, leading to less ATP and more ROS production, and a fourth one to bacterial translocation through a damaged gut mucosa, which may sustain mucosal inflammation and permeability