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Incubation of the thiol product with a microsomal thiomethyltransferase and S -adenosylmethionine yielded the corresponding thiomethyl compound (Tateishi et al., 1978a)

For dogs - who have shorter digestive tracts than humans - this improved delivery mechanism is especially important for getting a meaningful therapeutic dose

This is particularly relevant for severe, corticosteroid-resistant asthma, where unmet therapeutic needs remain substantial