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Compromised GSH concentrations and diminished redox status in humans occurs over age 45, and A precipitous decline in GSH/GSSG redox occurs, along with a linear oxidation of cysteine/cystine redox state with age at a rate of 0.16mV/year over the entire age span (in plasma), GSH/GSSG redox was not oxidized prior to 45 years and subsequently was oxidized at a nearly linear rate of 0.7 mV/year

[DOI] [Google Scholar] 209.Yamaki T., Nuryanthi N., Kitamura A., Koshikawa H., Sawada S., Voss K.-O., Severin D., Trautmann C

All these have major adverse effects and generally are less effective than Sinemet in suppressing symptoms

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