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Therefore, the development of combination therapies requires a comprehensive understanding of immune functions in metabolic hepatic disease, as extensively discussed in our recent review (175)

Heatmaps showing z-score normalized median expression levels were created using R package pheatmap, all correlations were performed in R using the packages ggcorrplot, principal component analyses were performed using MMIs for each sample using the stats package in R

However, although some successful examples of color modification have been described in rose, carnation and Nierembergia , undesirable results were also reported probably because tissue-specific promoters were not used, adding to the difficulty in obtaining stable phenotypes (Tanaka et al., 2009, 2010)