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Additionally, CS exposure also disrupts the extracellular matrix during COPD (Shapiro and Ingenito, 2005), which could subsequently promote FAO in EpiC (Schafer et al., 2009)

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The immune system recognizes pattern recognition receptors of infective pathogens (PARPs), and the stimulation of the immune system leads to the secretion of pro-inflammatory cytokines such as interleukin 1 (IL-1) and tumor necrosis factor- (TNF-) and anti-inflammatory biomarkers