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10.1056/NEJMra1205750 New Engl

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For example, while low-dose polyphenols stimulate endogenous antioxidant defenses, high concentrations, such as those found in concentrated supplements, can act as potent pro-oxidants, leading to increased oxidative stress and cellular damage 51

The body has learnt how to defend itself from these wayward molecules by producing endogenous antioxidants, and by drawing on protective compounds provided by the diet, such as vitamins C and E