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In contrast, this treatment significantly downregulates the expression of cholesteryl esters (CEs) and TAGs by inhibiting the de novo synthesis of cholesterol and fatty acids, as demonstrated by isotope-tracing experiments and the downregulating effects of SREBF2 and ACLY expression 106

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Definitions of antidepressant treatment response, remission, nonresponse, partial response, and other relevant outcomes: a focus on treatment-resistant depression

As we will discuss in the clinical evidence section, the story becomes more complicated when you move from animal models to human trials