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Cortisol dysregulation also becomes more pronounced as estrogen withdrawal activates the HPA axis, producing the elevated baseline stress-hormone output that drives the "tired but wired" pattern common in midlife women
Jason B London B12 deficiency is not something to be taken lightly and having injections for the sake of it just in case is foolhardy because ignorance amongst physicians is dramatic and if you do have a serious deficiency, ignorance amongst clinicians can greatly decrease your quality of life and even lead to death if not correctly diagnosed and treated
doi: 10.3389/fonc.2025.1712576 Received 24 September 2025 Revised 07 November 2025 Accepted 21 November 2025 Published 10 December 2025 Volume 15 - 2025 Edited by Egidio Iorio, National Institute of Health (ISS), Italy Reviewed by Leandro Jos de Assis, University of Plymouth, United Kingdom Rosa Anglica Castillo-Rodrguez, Instituto Politecnico Nacional, Mexico Updates Copyright 2025 Chung, Saad, Kafri, Rossignol, Verbrugge and Bakke
