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CARDIOVASCULAR HEALTH Cardiac Function Ejection fraction: improvement of 1015% in heart failure models Wall thickness VI: increase in functional myocardial mass 8% Diastolic function: E/A ratio improvement Exercise capacity: increase in VO max 12-18% Cardiovascular Metabolism Lipid profile: LDL 1015%, HDL 812% Endothelial function: improves endothelium-dependent vasodilation 25% Arterial stiffness: reduced pulse wave velocity 10% Blood pressure: systolic decrease 5-8 mmHg 5

Since several class I GRXs become more active when mutated for their resolving cysteine residues 43,44,45 , we changed the ROXY9 CCLC signature into CCLS

Highquality nasal sprays, like Synchronicity Healths NAD+ Nasal Spray and Glutathione Nasal Spray , offer strong bioavailability with athome convenience, making them an appealing middle path for sustained use

eBioscience), CD11c (AF700