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Astrocytes, positioned at the interface between the brain parenchyma and the perivascular space, which includes capillaries, larger arteries, and veins [66], play a role in the removal of A from the brain via mechanisms that include enzymatic degradation of A and the upregulation of efflux transporters for A at the BBB [67]

Bloodstream infections (BSI, i.e., bacteremia) are a common type of infection in patients with ESLD, which are associated with high mortality, longer length of hospital stay and faster escalation of the liver disease

Well-researched with decades of clinical data

Scientific understanding on how the formulation, the inhalation device and relevant physiology impacts the drug product performance is the mainstay of an inhaled biopharmaceutics representative assignment in the industrial setting