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In adipocytes, the binding of nicotinic acid to GPR109A was found to initiate a signal transduction cascade resulting in reductions in free fatty acid production via the inhibition of hormone-sensitive lipase involved in triglyceride lipolysis (21)

Jafari-Sales A, Shariat A, Baghi HB, Baradaran B, Jafari B

By modulating iron metabolism, estrogen reduces ferroptosis, potentially offering protection to cancer cells against the damaging effects of ferroptosis [97]