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The hMPV F polypeptide or nucleic acid molecule of any one of claims 8-14, wherein said prefusion F polypeptide further comprises an Fo cleavage site mutation comprising amino acid substitutions Q100R and S101 R, replacing glutamine at amino acid position 100 of SEQ ID NO: 1 with arginine, and replacing serine at amino acid position 101 of SEQ ID NO: 1 with arginine

Scientists extracted and synthesized the active fragment we now call BPC-157, which weighs just 1,419 daltons

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Thus, selective c-Met inhibitors may be a better choice for treatment in patients and more studies are needed to identify the reason for phase II clinical trial failure and the feasibility of using c-Met targeting therapies