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In contrast, modern trial frameworks incorporate molecular stratification, longitudinal monitoring, and adaptive decision-making to align treatment with evolving tumor biology (208, 209)

The intermediate content was collected, stored in amber Eppendorf tubes, and kept in a freezer at -80C until analysis

Both hypokalemic and hyperkalemic forms of familial periodic paralysis exist, although the increase in the plasma potassium level is typically small and may not exceed the normal range in the latter