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Indeed, inflammatory mediators generated in the periphery, as well as insults within the brain, can activate brain-resident immune cells, resulting in a neuroinflammatory response that interferes with the multitude of neurobiological mechanisms implicated in the pathogenesis of depression

Schwartz K, Chang HT, Nikolai M, Pernicone J, Rhee S, Olson K et al

In contrast, the levels of betaine, creatine, myo-inositol, choline, glutamine, acetate, propionate, isobutyrate, citrate, fumarate, taurine, Met, tyrosine, isoleucine, glycine, threonine, and phenylalanine were significantly increased in the D + MS group compared to those in the D + ND group, and 3-hydroxybutyrate, pyruvate, allantoin, N-acetyl glycoprotein, O-acetyl glycoprotein, and urea levels were significantly decreased in the D + MS group compared to those in the D + ND group (Fig

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