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Therefore, at present, many elderly diabetic patients who have no obvious response or intolerance to hypoglycemic effects from Western medicine prefer to choose alternative treatment methods, such as herbal medicine or TCM, thus making alternative treatment for diabetes a popular treatment method

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In other cases, however, IVIG therapy is typically reserved for those with refractory muscle, skin, or other DM manifestations due to cost, limited supply, and logistical inconveniences of infusions

The activation of 4-1BBL + B cells with CD40 agonism and IFN- stimulation has been correlated to amplification of the antigen-presenting capacity, therefore skewing cytokine production towards a more pro-inflammatory phenotype, and ultimately supporting robust CD8 + T cell responses (148)