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Curr Mol Med 13(4):514534 McBrayer SK, Mayers JR, DiNatale GJ et al (2018) Transaminase inhibition by 2-hydroxyglutarate impairs glutamate biosynthesis and redox homeostasis in glioma

In vivo experiments further suggested that an administration of leucine exacerbated the process of AILI through activating the Hippo signaling pathway

Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells

Excessive glutamate intake can also contribute to neurotoxicity, especially in vulnerable populations with pre-existing neurological conditions