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Dass et al., 2003

(1) Systemic entry and uptake: Tyramine escapes normal intestinal and hepatic metabolism, enters the circulation, and is transported into sympathetic nerve terminals via the norepinephrine transporter (NET)

Surprisingly, MdfA also confers resistance to therapeutically significant antibiotics with unrelated chemical structures, including erythromycin, chloramphenicol, certain aminoglycosides, and fluoroquinolones ( When mdfA and acrAB are overexpressed together, quinolone resistance increases synergistically