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Researchers observed that kisspeptin-10 binding to KISS1R activates phospholipase C, generating IP3 and DAG, leading to intracellular calcium mobilization and PKC activation in GnRH neurons

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Depletion of GPX4 has been shown to substantially sensitise to ferroptosis induction 11 , and degradation of ferritin may increase free Fe2+ production leading to ferroptosis susceptibility 33,34

Therefore, we examined the expression of other mitochondrial regulators (AMPK, SIRT1, and NRF2) in AMSCs-treated mice and found that AMSC therapy increase the expression of NRF2 in AILI, but there is no significant increase in the activation of AMPK and the expression of SIRT1 (Fig