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In this mouse model, 7585% decrease of Gpx4 was shown to induce hippocampal neuronal loss, lipid peroxidation, neuroinflammation and spatial learning deficits (Hambright et al., 2017)

Zhai, Y.N., Huang, M.X., Jiang, L.F., and Liao, H.L., J

doi: 10.1517/17425255.2.3.351 99 YamasakiMMakinoTMasuzawaTKurokawaYMiyataHTakiguchiSet al

One study looked at 84 patients with marginal ulcers and described the appearance as single or multiple infiltrates, which subsequently coalesced with overlying epithelial breakdown of the corneal epithelium