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It also plays an important role in over 100 enzyme reactions

doi: 10.1074/jbc.RA119.008725 36 GokulanathanA.MoH

For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses