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Six were depleted in the frail brain, including cytoskeletal proteoforms derived from MAP2, -tubulin and vimentin, whilst 16 were increased with cognitive frailty, including CHGA/B, CCK and other cytoskeletal peptides such as -tubulin and PALM (Fig

Doses higher than 60mcg/kg of body weight can lead to hGH peaks reaching up to 26.6ng/ml (80mIU/l) [17]

Mechanistically, DUSP6 dephosphorylates the transcription factor FOXO1 at Ser256 residue, promoting the nuclear translocation of FOXO1 and subsequent transcription of the transcription coactivator PPAR- coactivator 1 (PGC-1)

Its structure mimics a portion of the natural Thymosin Beta-4 peptide