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Both incretins are involved in many biological functions (153)

Through its action on ATF4, HRI upregulates SESTRIN2 and REDD1 (stress-induced protein, generally upregulated by DNA damage and ROS)

Interestingly, in SARS-CoV-2, TLR2 is a critical mediator of envelope protein detection and driver of pathogenesis through inflammatory process augmentation [44]