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NOCs can lead to DNA alkylation, which can induce genetic mutations that ultimately lead to cancer ( 2 S, which can promote the occurrence of CRC by inhibiting butyrate oxidation, destroying the intestinal barrier, and interacting with ROS to induce DNA damage ( Dietary fiber can increase intestinal peristalsis, promote stool excretion, and reduce the food transit time in the colon, thus reducing the contact time of potential carcinogens with intestinal mucosa ( 2.1.2 Familial inheritance Approximately 20-30% of CRC cases are associated with genetic factors, 2-5% of CRC is caused by inherited syndrome, mainly including Lynch syndrome, familial adenomatous polyposis, juvenile polyposis syndrome, MUTYH -associated polyposis, and Peutz-Jeghers syndrome etc ( 2.1.3 Polyps The incidence of CRC is closely related to polyps

The hafnium foundation organic framework (HfMOF-PEG-FA) modified with folate increases radiation dose deposition and subsequent production of ROS, promotes IFN regulatory factor (IRF) stimulation, and in combination with the TLR7 agonist imiquimod enhances immune activation, characterized by an increase in CD8 + and proliferative T cells (143)

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