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5.2.2 Limitations due to the disease The pathophysiology of mutations or mechanisms underlying the neuronal pathology of mitochondrial diseases is still unknown in most patients, which makes it difficult to interpret the mitochondrial or neural readout in pharmacological screenings

CBD can also indirectly influence cellular activity by altering the release of neurotransmitters or cytokines from neighbouring cells, leading to non-cell autonomous effects

doi: 10.1186/s12964-025-02041-1 6 EduardoPMKaplanMJ

Meanwhile, toxicity studies have suggested that paeoniflorin has low acute toxicity, minimal subacute and chronic toxicity, and no genotoxic or mutational toxic effects